Anti-Apoptotic Mechanisms of Sertoli Cells against Ethanol Toxicity

Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: mechanisms and consequences.

More than half of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa during mammalian spermatogenesis. These cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells, a testicular somatic cell type possessing phagocytic activity. We have investigated the mechanism by which Sertoli cells specifically recognize and phagocytose apoptoti...

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance

In the human body, billions of cells die by apoptosis every day. The subsequent clearance of apoptotic cells by phagocytosis is normally efficient enough to prevent secondary necrosis and the consequent release of cell contents that would induce inflammation and trigger autoimmunity. In addition, apoptotic cells generally induce an anti-inflammatory response, thus removal of apoptotic cells is ...

Role of apoptotic and anti-apoptotic mechanisms in erythroblast differentiation

Anti-apoptotic effects of tamarind leaves against ethanol-induced rat liver injury.

OBJECTIVES The leaf decoctions of Tamarindus indica (TI) have long been traditionally used in liver ailments. The aim of this study was to investigate the anti-apoptotic activity of TI leaf extract against acute ethanol (EtOH)-induced liver injury. The major constituents of the extract were also examined for standardization purposes. METHODS Rats (n = 5-7) were orally pretreated with TI leaf ...

anti-proliferative and apoptotic activities of chrysin in neuroblastoma cells